Program areas at Xenobe Research Institute
National Institutes of Health Grant R21NS128597. While well established as clinical targets, the lack of molecular probes to the large immunophilins continues to inhibit our ability to evaluate and drug them clinically. This program explores the development of a general platform to discover probes that target specific domains within a neurological protein. Using cyclophilin 40 (Cyp40), FK506-binding proteins FKBP51 and FKBP52, our team seeks to define critically needed reagents to understand the role of the `large immunophilin' family in neurological disease. We began studies on our recently funded R21 program and have reported signficance success within our initial year of funding.The revenue generated will be used for the latter half of the program. A two year award was provided within this funding period. These funds to cover salaries, research supplies, instrument time, and equipment access to complete these studies.
National Institutes of Health Grant R01CA236352 via a Salk Institute Sub-Award. Studies associated with sub-award associated with NIH grant R01CA236352 were conducted. These studies focused on developing methods for plant natural product production, isolation and structure elucidation. As well as the preparation of probes and synthetic materials. The remaining funds are being used to support the ongoing efforts towards this program.
Varigen Biosciences / Terra Bioworks. Granted funding was provided to support small molecule isolation and structure elucidation efforts. These funds were used to cover research supplies, instrument time, and equipment access to complete these studies. Two publications were published: Pham NT, Alves J, Sargison FA, Cullum R, Wildenhain J, Fenical W, Butler MS, Mead DA, Duggan BM, Fitzgerald JR, La Clair JJ, Auer M. Nanoscaled Discovery of a Shunt Rifamycin from Salinispora arenicola Using a Three-Color GFP-Tagged Staphylococcus aureus Macrophage Infection Assay. ACS Infect Dis. 2023 Aug 11;9(8):1499-1507. Stankey RJ, Johnson D, Duggan BM, Mead DA, La Clair JJ. A Survey of Didemnin Depsipeptide Production in Tistrella. Mar Drugs. 2023 Jan 17;21(2):56. doi: 10.3390/md21020056.
Grant from Metabolon. Funds were provided to guide synthesis of an unknown natural product including providing spectroscopic services. Funds were used to sponsor lecture costs as well as conduct spectroscopic services.