Program areas at Alzheimer's Research Foundationfisher Center
Fisher drug discovery resource center:a grant was made to The rockefeller university for The Fisher drug discovery resource Center located at The rockefeller university's bronk laboratory building to help drive transformational science and fuel The development of innovative therapeutics with high-throughput and spectroscopy resource Center (htsrc). High-throughput screening and other technologies enable The identification of therapeutic targets for potential preventions or effective treatments of virtually any human disease.
4c. Casanova sars-cov-2 infection:a grant was made to dr. casanova's Research on understanding The life-threatening manifestation of sars-cov-2 infection. His laboratory discovered The human determinants of life-threatening covid-19 pneumonia in at least 20% of patients, with inborn errors of and auto-antibodies to type i interferons. Sars-cov-2 will continue to infect unvaccinated individuals for The foreseeable future and will increasingly infect vaccinated individuals as immunity wanes or as viral variants appear that evade existing vaccine targets. The emergence of viral variants with greater fitness/transmissibility and immune evasion potential exacerbates The threat to human health, as tragically illustrated with life-threatening "breakthrough cases". Their approach is to counterattack The viral challenge using synergistic genomic and immunologic approaches. Their studies include deep analysis of inter-individual genetic variability, building on discovery of germline human genetic variants and their autoimmune phenocopies predisposing to poor outcome.
The Zachary and Elizabeth M. Fisher Center for Research on Alzheimer's disease (The Fisher Center lab):the principal activity of The Fisher Center for Alzheimer's Research Foundation is to provide funding to The Fisher Center lab at The rockefeller university, one of The largest and most modern facilities in The world dedicated to solving The puzzle of Alzheimer's disease. Currently led by newly appointed director, dr. nathaniel heintz, The james and marilyn simons professor at The rockefeller university. The Fisher Center has provided researchers around The globe with a conceptual framework for understanding The disease process and continues to be at The forefront of one day finding a cure for Alzheimer's disease (ad).
The rockefeller university greengard professorship in neuroscience:the organization provided funding for The paul greengard professorship in neuroscience at rockefeller university in honor of The late nobel laureate and his 35 year tenure with The university.
The Fisher Center Foundation information program:our information program promotes disease awareness, education and resources for people with alzheimer's, their family, friends and caregivers. Information is dispersed through social networks, electronic and physical mailings, and The internet. Our website, alzinfo.org, is updated regularly to provide comprehensive data about Alzheimer's disease, recent Research studies and findings, treatment, and disease management. The site has over 434,000 unique visitors a year. Our magazine, preserving your memory, circulates over 50,000 copies per issue and continues to win awards based on its editorial content as it addresses readers' concerns over diagnosis and progression of Alzheimer's disease. Our free bi-weekly e-newsletter, Alzheimer's Research news you can use, continues to be The most reviewed Alzheimer's and dementia newsletter on The internet with over 10,000 subscribers. Our social media presence continues to grow, driving followers to our website to seek out other information program materials.
A grant was given to a european Center of Research, care and education on genetic diseases to investigate whether structure of amyloid proteins are changed particularly if proteins aggregates, which are toxic for synapses, are decreased. In this hypothesis, masitinib maydecrease protease release by mast cells, which may be responsible for generation of proteins aggregate, and test whether masitinib is able to block lesions spreading after prions like proteins inoculation. This project will reveal role of mast cell and kinases in The pathophysiology of alzheimer disease. A better understanding of its mechanisms may define The best strategy to improve Alzheimer's disease.